Affiliated Faculty

This list of affiliated investigators can help you identify potential research mentors at the University of Pittsburgh. PSTP students can, and do, work with mentors not on this list, but the investigators featured below have expressed interest in hosting PSTP students in their laboratories.

Christopher Bakkenist, PhD
Research Areas Research Summary

Identify phosphorylations, dephosphorylations and acetylations that regulate ATM activity in vivo

Timothy F. Burns, MD, PhD
Research Areas Research Summary

Development of targeted therapies for KRAS mutant NSCLC; Reactivation of OIS and apoptosis; Mechanisms of acquired resistance to targeted agents

Clifton Callaway, MD, PhD
Research Areas Research Summary

Improving recovery from brain injury after cardiac arrest

Yuanyuan Chen, PhD
Research Areas Research Summary

The Chen lab is interested in the pharmacological studies of visual disorders caused by protein misfolding. The lab's current three projects include pharmacological studies of rhodopsin metabolism, roles of purine metabolites in photoreceptor degeneration, and drug discovery of myocilin-associated glaucoma.

Donald DeFranco, PhD
Research Areas Research Summary

Steroid hormone action in neural stem cells and cancer

Bruce Freeman, PhD
Research Areas Research Summary

The production and signal transduction properties of oxidizing and free radical mediators in metabolic, respiratory and cardiovascular diseases

Edwin K. Jackson, PhD
Research Areas Research Summary

The biochemistry, molecular/cell biology, and physiology/pharmacology of adenosine

Lawrence Kane, PhD
Research Areas Research Summary

Signal Transduction; The role of the Akt kinase in NF-kB and T cell activation; Role of TIM proteins in T cell activation

Thomas Kleyman, MD
Research Areas Research Summary

Cellular, structural and molecular studies of epithelial ion channels

Adrian Lee, PhD
Research Areas Research Summary

Molecular profiling (genomic, transcriptomic, proteomic) of women’s cancers, mouse modeling, and predictive biomarkers for targeted therapy

Steffi Oesterreich, PhD
Research Areas Research Summary

Hormone response and treatment resistance in breast and ovarian cancer, including the analysis of aberrant genetic and epigenetic changes

Patrick Pagano, PhD
Research Areas Research Summary

NADPH oxidase (Nox) & reactive oxygen species in signaling, vascular dysfunction and cardiopulmonary disease; Nox drug therapy development

Francisco Schopfer, PhD
Research Areas Research Summary

Lipid signaling mediators associated with inflammation

Sruti Shiva, PhD
Research Areas Research Summary

Understanding the mechanisms by which mitochondrial function is regulated, particularly by reactive oxygen and nitrogen species and the contribution of these mechanisms to cardiovascular health and disease pathogenesis

Richard Steinman, MD, PhD
Research Areas Research Summary

Mechanisms of white blood cell differentiation & its inhibition in leukemias; Mechanisms of stem cell differentiation & growth control

Adam Straub, PhD
Research Areas Research Summary

The Straub laboratory investigates redox cell signaling mechanisms that control endothelial and smooth muscle biology in the microcirculation.

Changfeng Tai, PhD
Research Areas Research Summary

Neural control of low urinary tract and neuromodulation of bladder dysfunction

Ben Van Houten, PhD
Research Areas Research Summary

Repair of DNA damage in nuclear and mitochondrial genomes; Structure and function of nucleotide excision repair proteins

Peter Wipf, PhD
Research Areas Research Summary

Drug discovery and drug development, employing organic synthesis, medicinal chemistry and molecular modeling to develop new therapeutic agents for cancer and neurodegenerative diseases in a highly collaborative environment

Yan Xu, PhD
Research Areas Research Summary

Designed receptors as therapeutic targets for pain; Mechanisms of low-affinity drug action; Mapping of unconscious brain; Stem cell therapy for stroke

Lin Zhang, PhD
Research Areas Research Summary

Genetic basis of differential sensitivity to anticancer drugs; Genetic alterations that cause drug resistance; Mechanisms of drug-induced apoptosis