Affiliated Faculty
This list of affiliated investigators can help you identify potential research mentors at the University of Pittsburgh. PSTP students can, and do, work with mentors not on this list, but the investigators featured below have expressed interest in hosting PSTP students in their laboratories.
![Kalil Abdulla, MD](/sites/default/files/styles/person_image/public/person-img/abdulla.png?h=2d8a33df&itok=H9oym-8h)
Brain tumors, hydrocephalus, Chiari malformations, trigeminal neuralgia, and traumatic br
![Taylor Abel, MD](/sites/default/files/styles/person_image/public/person-img/abel_taylor.jpg?h=86e9e3af&itok=dQVkQzfz)
Neural mechanisms of visual and auditory perception.
![Sameer Agnihotri, PhD](/sites/default/files/styles/person_image/public/person-img/agnihotri_sameer_rs.jpg?h=b0a5c3dd&itok=tpXihSy2)
The Brain Tumor Biology and Therapy Laboratory studies pediatric and adult high-grade gliomas (HGG)—focusing on brain tumor signing, glioma metabolism and using genomics to identify novel and effective therapies.
![Susanne E Ahmari](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%209.50.26%20AM.png?h=bca18399&itok=dUzqJGuu)
The Ahmari Lab investigates the molecular, cellular, and circuit mechanisms underlying repetitive and compulsive behaviors in preclinical models and translates findings into the clinic through collaborative research studies in people with OCD.
![Katherine Aird](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202024-01-08%20at%2012.40.29%20PM.png?h=6f387c1e&itok=wr1S4E5K)
The Aird Lab studies the bidirectional interplay between cellular metabolism and the cell cycle in cancer.
![Elias Aizenman](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-11%20103631.png?h=1fc8e385&itok=7B6gWjnZ)
Cellular and Molecular Basis of Neurodegeneration
![Aizenstein](/sites/default/files/styles/person_image/public/person-img/aizenstein.jpg?h=2822aae3&itok=eDjBRwHe)
Cellular and Molecular Basis of Neurodegeneration
![Jonathan Alder](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2010.04.48%20AM.png?h=6676d2f0&itok=MUhuPKmb)
The Alder lab focuses on understanding the contribution of telomere length to human health and disease.
![Ambrose](/sites/default/files/styles/person_image/public/person-img/ambrose.jpg?h=7d752faa&itok=GnSUdBIP)
HIV infection and therapeutics
![William Anderst](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202024-05-13%20at%2010.36.34%20AM.png?h=7079e290&itok=tEuQZfPH)
The Biodynamics Lab investigates the effects of age, injury, surgery, and rehabilitation on dynamic joint function.
![Apodaca](/sites/default/files/styles/person_image/public/person-img/apodaca.jpg?h=b0a5c3dd&itok=xlI1f0Yl)
Endocytic pathways and stretch-regulated endocytosis/exocytosis in bladder
![photo](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-01%20at%203.49.28%20PM.png?h=7f4824b7&itok=UHtYcYB9)
Tissue Engineering and Regenerative Medicine, emphasis upon clinical application; Cell:biomaterial interactions; Epimorphic regeneration in mammals
![Kelly Bailey](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-14%20at%209.18.17%20AM.png?h=36e28827&itok=eLrfNGeE)
The Bailey laboratory focuses on the intersection of DNA damage and immunobiology in Ewing sarcoma, a primary bone tumor diagnosed in adolescents.
![Bakkenist](/sites/default/files/styles/person_image/public/person-img/bakkenist.jpeg?h=1364cbab&itok=Nl9_F2Hh)
Identify phosphorylations, dephosphorylations and acetylations that regulate ATM activity in vivo
![Batista](/sites/default/files/styles/person_image/public/person-img/batista.png?h=00094a30&itok=BQ2AxgDA)
Neurophysiology of sensory-motor coordination, brain-machine interfaces
![Becker](/sites/default/files/styles/person_image/public/person-img/becker_jason_rs.jpg?h=56f5ab0f&itok=6ZQ7Po2R)
Investigation of the molecular mechanisms that regulate the pathogenesis of genetic and acquired cardiomyopathies
![Kambez Benam](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2010.15.41%20AM.png?h=a8a10c01&itok=mGoXzxoV)
Dr. Benam is the founder of Translational and Multidisciplinary Lung Microengineering Lab, which brings together researchers from the engineering, biology, bio-pharmaceutical industry, clinical and business communities with the aim of developing new technologies that recreate complex human organ pathophysiology in vitro, and applying them to discover novel therapeutics and personalized biomarkers. His research focuses on applying disruptive technologies that enable him and his team to elucidate cellular and molecular mechanisms that govern tissue pathology or offer protection during lung injury and host-environment interaction.
![Photo](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-01%20at%203.50.29%20PM.png?h=241053b7&itok=w-S1y8ij)
The Billiar Lab focuses on the immune responses to acute systemic stresses of major clinical relevance including trauma and surgical sepsis
![Binder](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-01%20at%204.01.12%20PM.png?h=7b32e013&itok=mIL5ugPC)
The mechanisms of cross-priming of antigens during immune responses to cancer, viruses and autoimmunity
![Borghesi](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-01%20at%204.01.43%20PM.png?h=6d512152&itok=ptmKeNPk)
Demand adapted hematopoiesis in infection and inflammation
![Miguel Brieno-Enriquez](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2010.10.53%20AM.png?h=c47e95dc&itok=JGOAP7rG)
Research in the Brieño-Enríquez lab focuses on the regulation of gametogenesis and reproductive aging in mammals (human, mouse and naked mole-rat) and, more specifically, the fundamental mechanisms that are required to produce viable germ cells and maintain them along the lifespan.
![Brodsky](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-01%20at%204.02.25%20PM.png?h=57d00edb&itok=Et9CHLUt)
Protein “quality control”, diseases associated with misfolded proteins, and drug treatments for these diseases
![Buckanovich](/sites/default/files/styles/person_image/public/person-img/Buckanovich.jpg?h=aaa558d5&itok=BLEu7-h8)
Tumor microenvironment, Cancer stem cells, novel therapeutics for cancer
![Burns](/sites/default/files/styles/person_image/public/person-img/burns_t6211.jpg?h=9a247a60&itok=ceB2VGDm)
Development of targeted therapies for KRAS mutant NSCLC; Reactivation of OIS and apoptosis; Mechanisms of acquired resistance to targeted agents
![Byrne](/sites/default/files/styles/person_image/public/person-img/Byrne.png?h=bfc65b92&itok=cicTkbKL)
Gene therapy, viral vector engineering, genome editing, inherited retinal degeneration, genetics of eye disease
![Callaway](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%201.18.13%20PM.png?h=97e9b2ee&itok=J8fRQT7l)
Improving recovery from brain injury after cardiac arrest
![Franca Cambi](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202024-05-13%20at%2010.41.21%20AM.png?h=073616cc&itok=Eit4pLn8)
The overarching goal of my research is to elucidate the molecular mechanisms that underlie oligodendrocyte and myelin mediated support to neuronal cell and neural circuitry integrity in models of neurodegeneration.
![Chalasani](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%201.19.45%20PM.png?h=741212e3&itok=m9SNhXTO)
Understanding how memory T cells are generated in transplantation
![Chan](/sites/default/files/styles/person_image/public/person-img/chen.png?h=14cbb0c9&itok=xMNlyeAr)
Basic science and translational research studying the molecular mechanisms of pulmonary vascular disease and pulmonary hypertension
![Chang](/sites/default/files/styles/person_image/public/person-img/changy.jpg?h=09dbf802&itok=YcVLanEU)
The study of human tumor viruses
![Cheetham](/sites/default/files/styles/person_image/public/person-img/cheetham.png?h=2df7df21&itok=aNuWRdDu)
Development, plasticity and regeneration of neural circuits
![Chen](/sites/default/files/styles/person_image/public/person-img/CHEN_YUANYUAN.jpeg?h=442108ff&itok=NoGcCNQE)
The Chen lab is interested in the pharmacological studies of visual disorders caused by protein misfolding. The lab's current three projects include pharmacological studies of rhodopsin metabolism, roles of purine metabolites in photoreceptor degeneration, and drug discovery of myocilin-associated glaucoma.
![Jay Chhablani Picture](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-05-30%20at%203.06.47%20PM.png?h=30f6f272&itok=6GEimLet)
Machine learning approach for OCT biomarkers identification in age-related macular degeneration
![Chu](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%201.20.39%20PM.png?h=00b7d3a2&itok=-SfSIqyX)
Redox signaling & autophagy in neuroprotection and neurodegeneration; Mitochondrial phosphoproteomics; Genetic & toxin models of Parkinson’s disease
![Clemens](/sites/default/files/styles/person_image/public/person-img/Clemens-Paula.jpeg?h=475b3600&itok=Y4pXm69W)
Models of muscle disease causing muscular dystrophy and muscle atrophy; Translational research for treatment of muscle disease
![Clermont](/sites/default/files/styles/person_image/public/person-img/clermont.jpg?h=922e280b&itok=KLQdSHLO)
Big data analytics, predictive modeling, and dynamic modeling of disease
![Coffman](/sites/default/files/styles/person_image/public/person-img/coffman.jpg?h=8adb4b32&itok=PnkTnRYb)
Stomal Interactions critical to the survival, growth, and spread of ovarian cancer
![Cui](/sites/default/files/styles/person_image/public/person-img/cui.png?h=37e78434&itok=_IxcAGsj)
The intersection of neural engineering and biomaterials with specific focus on neural electrode-tissue interface, neural tissue engineering, biosensor and drug delive
![Christopher Cunningham](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-14%20at%209.38.45%20AM.png?h=5c14969e&itok=GMnBUhUM)
The Cunningham Lab studies molecular and cellular mechanisms of protein assembly and trafficking in the mammalian auditory system with an ultimate goal of developing therapies for hearing loss.
![Jishnu Das Photo](/sites/default/files/styles/person_image/public/person-img/jishnu.jpeg?h=ceeafa82&itok=s6UDI65_)
Our research focuses on the development and use of novel systems approaches to analyze high-dimensional immunological datasets, and elucidate mechanisms of immune regulation and dysregulation. Our previous work has utilized systems approaches to analyze Mendelian mutations in the context of three-dimensional protein-protein interaction networks, to understand molecular mechanisms of corresponding disorders. We have also developed network analyses frameworks to characterize the evolutionary dynamics of these protein networks. Another dimension of our past work has been the use of statistical methods for the analyses of high-dimensional data and machine-learning approaches to elucidate correlates of natural and vaccine-mediated immunity in HIV, tuberculosis and malaria.
![Davidson](/sites/default/files/styles/person_image/public/person-img/davidson.png?h=9a247a60&itok=2Ttc0AZp)
Our group combines experimental and theoretical approaches to reverse-engineer the inherently mechanical processes of cell and tissue development.
![Davis](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%201.21.15%20PM.png?h=f16b4347&itok=ZsTyc18H)
Cellular and molecular mechanisms of central and peripheral nervous system development and plasticity
![DeFrances](/sites/default/files/styles/person_image/public/person-img/Final.DeFrances.2009.6.jpg?h=d496b270&itok=oDcEAv0x)
HGF-MET-PI3K signaling in liver development, growth, regeneration and cancer. She has identified a novel regulator of the catalytic subunit of PI3K (p110) called PI3K interacting protein 1 (PIK3IP1)
![DeFranco](/sites/default/files/styles/person_image/public/person-img/defranco.png?h=3fd5ab66&itok=IdopHoL9)
Steroid hormone action in neural stem cells and cancer
![Delgoffe](/sites/default/files/styles/person_image/public/person-img/delgoffe.jpeg?h=b8a41f36&itok=fu1Utf7z)
The metabolic regulation of T cell function, with a specific focus of those T cells that infiltrate the nutrient-poor tumor microenvironment
![DeLuca](/sites/default/files/styles/person_image/public/person-img/deluca.jpg?h=dc7250ff&itok=8Ckl2J0P)
HSV gene expression in productive and persistent infections
![Dermody](/sites/default/files/styles/person_image/public/person-img/dermody.jpeg?h=013cd1e9&itok=NDsCGRcW)
Research in the Dermody laboratory focuses on the molecular mechanisms of Mammalian Orthoreovirus (reovirus) and Chikungunya virus infections
![Berthony Deslouches](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-14%20at%209.21.04%20AM.png?h=7416f0c0&itok=lJXdcZ3B)
The design and development of cationic peptides as an effective countermeasure to the persistent problem of antibiotic resistance and other types of hard-to-treat infectious diseases.
Decision processes in late-life suicidal behavior and in borderline personality
![Donnelly](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%201.26.53%20PM.png?h=3076e9aa&itok=dBmm2fwR)
The molecular pathogenesis of neurodegeneration and aging
![Andrew Duncan](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2010.24.10%20AM.png?h=e528e142&itok=6gGXhTRf)
The Duncan lab studies liver homeostasis, regeneration, and injury, focusing on the role of hepatic chromosome variations (polyploidy and aneuploidy).
![Falo](/sites/default/files/styles/person_image/public/person-img/falo.jpg?h=1e89fca7&itok=clPnyOUq)
Developing a better understanding of cutaneous biology and skin immune function, and leveraging that evolving understanding to develop new skin-targeted strategies to modulate local and systemic immune responses
![Federspiel](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20105031.png?h=db020353&itok=_E_iKgRh)
Respiratory assist and blood processing devices for critical care medicine; Cardiovascular and pulmonary transport phenomena
The neurobiology of schizophrenia and neurophysiological abnormalities during wakefulness and sleep in early course psychosis
![Ferris](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%201.10.09%20PM.png?h=3e85f23a&itok=CZZqBBdc)
Mechanisms of immune escape and clinical translation to therapeutic cancer immunotherapy trials
![Finkel](/sites/default/files/styles/person_image/public/person-img/finkel.jpg?h=78909f5e&itok=sUVF48sM)
Intersection of mitochondrial function, metabolism and aging
![Flynn](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20105351.png?h=16e06af2&itok=5rkGigPE)
Immunology and Pathogenesis of Tuberculosis
![Freeman](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20105722.png?h=e87b888b&itok=64KMnPKG)
The production and signal transduction properties of oxidizing and free radical mediators in metabolic, respiratory and cardiovascular diseases
Dopaminergic signal transduction in the central nervous system, dopamine role in regulating peripheral pancreatic insulin secretion
![Friedlander](/sites/default/files/styles/person_image/public/person-img/Friedlander_0_1.jpg?h=77434360&itok=5rxo7yYn)
The study of the basic mechanisms of apoptosis, as mediated by the caspase apoptotic family in neurologic diseases
![Galson](/sites/default/files/styles/person_image/public/person-img/galson_deborah_rs.jpg?h=e51507b7&itok=FChKk690)
Roles of signal transduction pathways, transcription factors, and chromatin epigenetics in pathological changes in osteoclasts and osteoblasts in cancer-induced bone disease and Paget’s disease of bone
![Arjumand Ghazi](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2010.33.42%20AM.png?h=919beff7&itok=2o8Wezwg)
The Ghazi lab studies molecular genetics of aging and longevity, especially genes that link lifespan with healthspan and reproductive fitness.
![Avniel Ghuman](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-29%20at%204.55.45%20PM.png?h=6208c681&itok=fH7hZ2dt)
Our lab studies what human brain networks are doing using long-timescale recordings during real world behavior, as well as how our brains process social information during natural conversations.
![Gonzalez](/sites/default/files/styles/person_image/public/person-img/gonzales.png?h=1e89fca7&itok=7Q-b-SVt)
Exome and genome sequencing in newborns and genome sequencing in the Western Pennsylvania Amish and Mennonite communities
![Gonzalez-Martinez](/sites/default/files/styles/person_image/public/person-img/Gonzalez-Martinez.png?h=f4ba5523&itok=EcG9qbyS)
Adult and pediatric epilepsy surgery; movement disorder surgery; neuro-oncology; general neurosurgery
![Rachel Gottschalk](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2010.40.05%20AM.png?h=992c2a3f&itok=xd2iDcc5)
My laboratory is working to understand mechanisms controlling healthy versus pathological innate immune function, with major projects including interrogating lung-specific macrophage signaling and dissecting molecular determinants of monocyte and macrophage inflammatory function during lung infection.
![Grace](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20111636.png?h=5b66f9dd&itok=04Mu5ksn)
Neurophysiology of basal ganglia system related to psychiatric disorders
![Melanie Grubisha](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-01%20at%2011.06.01%20PM.png?h=a82e6f15&itok=WOE5L1xQ)
My work focuses on understanding both normal and abnormal adolescent dendritic development using preclinical models, focusing on how excitatory dendritic arbors stabilize across adolescence and what the functional implications are of impairments in these processes.
![Aditi Gurkar](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-14%20at%209.25.15%20AM.png?h=2a2e5c18&itok=8yxyE_g3)
The Gurkar lab is interested in understanding the causal molecular players in cellular senescence and aging.
![Costas Hadjipanayis](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2010.43.50%20AM.png?h=f805f754&itok=26hT09nQ)
Dr. Hadjipanayis and the Brain Tumor Nanotechnology Laboratory he directs focuses on translational research approaches for more effective treatment of malignant brain tumors that involve preclinical studies, imaging, rodent/larger animal brain tumor models, and actual human clinical trials.
![Hand](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%201.28.17%20PM.png?h=f507b233&itok=JTlWIhnC)
Understand the causes of diseases with disruptions between immune system and the microbiota, such as Crohn’s Disease and Environmental Enteropathy
![Hastings](/sites/default/files/styles/person_image/public/person-img/hastings.jpg?h=016c6704&itok=j35XEeLK)
Oxidative mechanisms associated with neurodegeneration
![Hempel](/sites/default/files/styles/person_image/public/person-img/Hempel.png?h=5428070e&itok=OzYfsb1p)
Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.
![Karl Herrup](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202024-05-17%20at%209.32.37%20PM.png?h=073616cc&itok=p6RMXqNa)
My laboratory works on the biochemistry and cell biology of neurodegenerative disease. Our main interest is Alzheimer's disease where our focus is the involvement of DNA damage, inflammation, and myelin.
![Andrew Hinck](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2010.49.34%20AM.png?h=5de2aad0&itok=-VMwLqNg)
We are interested in using the tools of structural biology to a) uncover the molecular adaptations that proteins of a highly diversified signaling TGF-beta signaling family have acquired to achieve their unique functions and b) leverage this knowledge to to develop targeted therapies for treating human disease, including soft tissue cancers and tissue fibrosis driven by dysregulated TGF-beta signaling and hereditary hemorrhagic telangiectasia caused by mutations in the receptors and co-receptors for BMP9 and BMP10.
![Ho](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20112349.png?h=a8c579c1&itok=Fqs3-vdr)
Chronic kidney disease (CKD) is a growing public health burden that results in significant morbidity and increased risk of mortality for individual patients
![Jackson](/sites/default/files/styles/person_image/public/person-img/jackson.jpg?h=db39da01&itok=Hibvc1tV)
The biochemistry, molecular/cell biology, and physiology/pharmacology of adenosine
![Max Joffe](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2010.53.47%20AM.png?h=3eb5e89b&itok=3EmA08JE)
We investigate how alcohol and drug use regulate or disrupt mechanisms of synaptic plasticity within the prefrontal cortex and we aim to use this knowledge to develop breakthrough psychiatric medications.
![Joglekar](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2010.57.17%20AM.png?h=43970fa2&itok=LzlyPJ36)
Systems level analysis of T cell repertoires to understand and engineer the immune system.
![Johnson](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%201.30.33%20PM.png?h=a12c9f5f&itok=fjToHhSd)
The Johnson lab studies the physiology, biophysics, structure, pharmacology, and regulation of glutamate receptors
![Kane](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%201.32.09%20PM.png?h=01115667&itok=fG3x7qFW)
Signal Transduction; The role of the Akt kinase in NF-kB and T cell activation; Role of TIM proteins in T cell activation
![Kaplan](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%201.32.57%20PM.png?h=e799e3d4&itok=1C9rWETo)
Role for nerves in the skin as modulators of immune responses
![Kaynar](/sites/default/files/styles/person_image/public/person-img/kaynar_400_2016.jpg?h=70f974ac&itok=V0KVSLrD)
Long-term outcomes following sepsis using a Drosophila as well as murine model of sepsis
![Kershaw](/sites/default/files/styles/person_image/public/person-img/kershaw.jpeg?h=0d7d336c&itok=We-86jrf)
The role of intracellular lipid metabolism and adipose tissue biology in normal metabolism and disease using basic and translational approaches
![Kim](/sites/default/files/styles/person_image/public/person-img/kim.jpg?h=6825595e&itok=FPprNFhK)
Develop & translate state of the art noninvasive imaging technologies to improve disease diagnosis, guide therapy, and evaluate therapeutic efficacy
![Kleyman](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%202.12.49%20PM.png?h=0500b006&itok=x4Ux1s4u)
Cellular, structural and molecular studies of epithelial ion channels
![Kliment](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20113704.png?h=3c5f4eb3&itok=p7-tUxqI)
Our laboratory is interested in the interplay of mitochondrial dysfunction and cellular senescence in lung epithelial and innate immune cells in the pathogenesis of chronic obstructive lung disease (COPD) and pulmonary fibrosis to improve therapeutic options for patients.
![Melanie Königshoff Picture](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-05-30%20at%202.27.40%20PM.png?h=ad927840&itok=nDZkyYwP)
Our research focuses on deciphering mechanisms involved in lung repair and regeneration, with the aim to identify novel therapeutic targets relevant for age-related chronic lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Our translational research program focuses on the comprehensive characterization of primary lung epithelial (stem) cells from experimental models and human tissue samples from patients with chronic lung disease. we aim to identify and investigate target signaling pathways that impact cellular mechanisms we identified the developmental WNT signaling pathway as a potent contributor to impaired lung repair and epithelial cell reprogramming, which is amenable to therapy and have further characterized features of epithelial cell reprogramming, such as cellular senescence. We further pioneered and apply patient-derived 3D Lung Tissue Cultures that allow to further validate and test potential novel drugs in an individualized fashion.
![Lagasse](/sites/default/files/styles/person_image/public/person-img/lagasse.jpeg?h=c846c355&itok=JL16yk5s)
Our research is focused primarily on stem cell biology and cell-based therapy for a variety of diseases including cancer and organ failure
![Lakkis](/sites/default/files/styles/person_image/public/person-img/lakkis.jpg?h=62a73c45&itok=2zWUashi)
Innate and adaptive immune response to transplanted organs and the mechanisms of transplantation tolerance
![Lee](/sites/default/files/styles/person_image/public/person-img/Adrian%20Lee_2Kx1K_0.gif?h=8eedd26c&itok=DKB6h9Ur)
Molecular profiling (genomic, transcriptomic, proteomic) of women’s cancers, mouse modeling, and predictive biomarkers for targeted therapy
![Arthur Levine Photo](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-05-30%20at%202.53.58%20PM_0.png?h=72f00026&itok=BWJU88hT)
Alzheimer's; Neurodegenerative diseases
![Lewis](/sites/default/files/styles/person_image/public/person-img/LewisDavid.jpeg?h=6ad2ba77&itok=cpF4nrbs)
Functional architecture of the prefrontal cortex and schizophrenia
![Lin](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20114517.png?h=0211c7eb&itok=FgGrghX6)
Our lab is focused on the host protective immune responses to M. tuberculosis, a major factor in outcome of infection.
![Little](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%202.38.21%20PM.png?h=da54b630&itok=6nsTS5Xj)
Drug Delivery, Biomimetics, Immunotherapeutics, Tissue Engineering, Biomaterials, Synthetic Systems
![Cecilia W. Lo](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2011.11.57%20AM.png?h=d52f0016&itok=2lN-nReA)
Genetics of congenital heart disease, role of epigenetics in adverse clinical outcome, disease modeling using patient derived induced pluripotent stem cells
![Lohmueller](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20114815.png?h=56bd80ed&itok=r9pkuldW)
The Lohmueller lab works on developing genetic engineering approaches to augment adoptive cell therapy (ACT) for the treatment of cancer.
![Luna](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20115016.png?h=948ccfc5&itok=_CJUxz3Z)
Brain basis of cognitive maturation through adolescence to adulthood
![Mann](/sites/default/files/styles/person_image/public/person-img/Mann-Melissa_4595.jpg?h=28ef9a56&itok=k5OwZ94b)
Molecular Regulation of Genomic Imprinting in Gametes and Early Embryos
![Manole](/sites/default/files/styles/person_image/public/person-img/manole_mioara_18308.jpg?h=d43f905b&itok=CZvKni4i)
Vascular pathways involved in cerebral vascular dysregulation and therapeutic strategies that improve neurological outcome after pediatric asphyxial cardiac arrest
![Marra](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%202.46.30%20PM.png?h=4682d5aa&itok=Iwug91r_)
Tissue engineering (peripheral nerve and soft tissue), wound healing, and adipose stem cell therapies
![Mars](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20115233.png?h=fff938d0&itok=6ZI2DwVg)
Understanding how cytokines and proteases controlling normal liver growth become deviant, leading to the development of cirrhosis and liver cancer
![Mcclung](/sites/default/files/styles/person_image/public/person-img/mcclung.jpg?h=d43f905b&itok=WWvMDdLx)
We are interested in the molecular mechanisms of psychiatric disorders with a particular focus on the role of the circadian clock in these disorders.
![Megli](/sites/default/files/styles/person_image/public/person-img/Megli.png?h=5f8e492b&itok=p75763x9)
Investigates how pregnancy modulates innate immunity and defines relevancy to infectious pathogenesis
![Marlies Meisel, PhD](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202024-02-08%20at%209.15.34%20AM.png?h=3435ff9f&itok=bL9iykA9)
The Meisel lab explores how the microbiota shapes systemic immunity that modulates the etiopathogenesis of complex diseases such as autoimmunity and cancer.
![Mellors](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%202.52.25%20PM.png?h=d128fb8a&itok=uiKUWRSc)
Mechanisms of HIV-1 persistence at the single cell level and evaluating strategies to cure HIV-1 infection, including latency reversing agents, monoclonal antibodies, cellular immunotherapy and therapeutic vaccines
![Meriney](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%202.57.19%20PM.png?h=135cf1e0&itok=zDtoBdQL)
Focuses on mechanisms of synaptic plasticity in the neuromuscular system in both normal and disease conditions
![Metes](/sites/default/files/styles/person_image/public/person-img/Metes_Diana.jpg?h=66c0dfaa&itok=RNOHtjKJ)
Human immunology: Innate and adaptive immune responses to latent viruses and to allo-antigens after organ transplantation
![Michalopoulos](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%202.58.07%20PM.png?h=e2c5a873&itok=A_bRE2VB)
Liver regeneration and carcinogenesis, exploring the effects of growth factors and associated signaling pathways
![Moalli](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%202.58.39%20PM.png?h=1bb20695&itok=tlSdzRVD)
Use of novel regenerative materials in repair of pelvic organ prolapse and urinary incontinence
![Kevin Mollen](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-01%20at%2011.08.57%20PM.png?h=52dcdd80&itok=qgV8J0SL)
Dr. Mollen's clinical interests include inflammatory bowel disease, thyroid surgery, anorectal malformations, and Hirschsprung’s disease. He is principal investigator of a NIH-funded research program investigating mitochondrial dysfunction during the pathogenesis of inflammatory bowel disease.
![Monga](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20115436.png?h=5cdfd76b&itok=IfGwTl8p)
Aimed at elucidating the cellular and molecular mechanisms of liver pathophysiology
![Morel](/sites/default/files/styles/person_image/public/person-img/Screenshot%202023-09-13%20115604.png?h=fb4e1fa1&itok=x034qVNU)
Autoimmunity & the control of T cell immune responses; Systems biology approaches to immune response to infectious organisms
![Morelli](/sites/default/files/styles/person_image/public/person-img/morelli.jpeg?h=300e9900&itok=AUbC_zWR)
The role of donor- and recipient-derived antigen-presenting cells (i.e. dendritic cells) and extracellular vesicles (i.e. exosomes, microvesicles) during allo-sensitization, graft rejection, and induction of donor-specific immunosuppression / tolerance, following transplantation
![Michael J. Morowitz](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2011.50.49%20AM.png?h=3da75ca3&itok=bbdWyTlk)
The Morowitz laboratory studies the effects of diet and antibiotics on interactions between the gut microbiome and the immune system.
![Morris](/sites/default/files/styles/person_image/public/person-img/morris.jpg?h=ac5d1431&itok=3pNIUGUx)
HIV-associated lung disease; HIV-associated emphysema; Role of Pneumocystis in COPD
![Mousumi Moulik](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-11-29%20at%2011.55.06%20AM.png?h=0d64fd92&itok=M8TxKsFU)
Moulik's clinical expertise is in cardiovascular genetics, cardiomyopathies, connective tissue disorders resulting in aortopathies, general cardiology and noninvasive cardiac imaging. She is the Director of the Cardiovascular Genetics Clinic at UPMC Children's Hospital of Pittsburgh. The focus of this clinic is to determine an underlying genetic etiology for inherited familial cardiovascular disorders including various forms of cardiomyopathies, heart rhythm disorders, aortic aneurysms, inherited lipid disorders, unexplained sudden cardiac arrest and help families with appropriate risk assessment and clinical screening of at-risk family members. Moulik also leads an NIH funded research lab with focus on heart failure signaling.
![Musahl](/sites/default/files/styles/person_image/public/person-img/Musahl.png?h=73a9d930&itok=VRBmqzbH)
Research interests include knee and shoulder biomechanics, specifically rotator cuff tears
![Muzumdar](/sites/default/files/styles/person_image/public/person-img/muzumdar.jpg?h=13879de6&itok=W9IK_fJE)
GH, insulin-like growth factors and a novel mitochondria-associated peptide on glucose homeostasis, energy metabolism, cardiovascular health and aging
![Neal](/sites/default/files/styles/person_image/public/person-img/NEAL.jpg?h=d145b9e0&itok=rdQNigoR)
The mechanisms of hemostasis and coagulation following trauma and hemorrhagic shock
![Kari Nejak-Bowen](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-01%20at%209.43.31%20PM.png?h=369b0e6d&itok=NONDXKUb)
Our lab studies the signaling processes and pathways in rare liver diseases, with a focus on cellular reprogramming, autophagy, and cell-cell interactions.
![Nimgaonkar](/sites/default/files/styles/person_image/public/person-img/Nimgaonkar.jpeg?h=d7671d3a&itok=QGG3FyHl)
Genetics of schizophrenia/bipolar disorder; functional genomics using induced pluripotent stem cell (iPSC) based models; gene/environment interactions
![O'Doherty](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%203.15.09%20PM.png?h=f37ca3b8&itok=QY6nRxYi)
The association between states of over nutrition and resulting metabolic disturbances, most notably obesity, NAFLD, and Type 2 Diabetes
Hormone response and treatment resistance in breast and ovarian cancer, including the analysis of aberrant genetic and epigenetic changes
![Abby Olsen](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-01%20at%209.46.49%20PM.png?h=77680c5f&itok=NEPq27uB)
The Olsen laboratory uses fruit flies, human cells, and mice to develop new therapies for Parkinson’s disease and related disorders.
![Opresko](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%203.15.31%20PM.png?h=ceeafa82&itok=ObOTbS_i)
Mechanisms for preserving telomeres in healthy cells to delay aging-related diseases including cancer, or that conversely deplete telomeres in cancer cells to stop their proliferation
![Orwig](/sites/default/files/styles/person_image/public/person-img/orwig.jpg?h=0edbcbe0&itok=R1M-Mln-)
Spermatogonial stem cells (SSCs) and male germ lineage development
![Hatice Osmanbeyoglu](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202024-06-27%20at%209.54.37%20AM.png?h=c971d799&itok=O2q9P3EV)
My group extracts biological insights and disease mechanisms from multiomics data including single-cell and spatially resolved data.
![Oury](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%203.15.46%20PM.png?h=f0dbf458&itok=loAtpuIo)
Oxidative mechanisms of pulmonary fibrosis, acute lung injury, inflammation, and pneumonia; The laboratory also studies the role of RAGE in the lung.
![Abby Overacre-Delgoffe](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202024-05-13%20at%2010.45.27%20AM.png?h=6ea4c2a5&itok=1Bkmzl6x)
My lab dissects the relationship between the microbiome and the immune system in the context of cancer and immunotherapy.
![Padiath](/sites/default/files/styles/person_image/public/person-img/Quasar%20S%20Padiath.jpg?h=7f67ae79&itok=UgKcb3XC)
Molecular mechanisms underlying various neurological disorders using human genetic approaches as well as research on animal and cell culture models
![Pagano](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%203.32.07%20PM.png?h=ec77df6d&itok=8aZPPgxF)
NADPH oxidase (Nox) & reactive oxygen species in signaling, vascular dysfunction and cardiopulmonary disease; Nox drug therapy development
![Pandey](/sites/default/files/styles/person_image/public/person-img/Pandey.jpg?h=89d836a6&itok=zRv47mBg)
Molecular mechanisms of amyotrophic lateral sclerosis (ALS)
Neuroimaging biomarkers of antidepressant treatment response in humans; Molecular bases of depression
![Julie Phillippi](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-01%20at%209.51.12%20PM.png?h=5a049b7a&itok=TID-g3C4)
Research in the Phillippi Lab is focused on microvascular dysfunction in cardiopulmonary disease, the role of perivascular progenitor cells, adventitial biology/biomechanics and vasa vasorum function in aortic disease and lung failure, cell-matrix interactions inciting vascular/microvascular matrix remodeling, pericytes in (patho)physiological vasculogenesis and angiogenesis, and tissue-engineered models of cardiovascular disease.
![Phillips](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-15%20at%209.45.28%20AM.png?h=df0c836f&itok=UP2QefTe)
Identification of neural correlates that underlie the symptoms of specific abnormalities in emotion processing in people with mood disorders
![Pirondini](/sites/default/files/styles/person_image/public/person-img/Pirondini.png?h=4aa4004b&itok=QDIlj9qR)
Stroke, motor control, proprioception, functional magnetic resonance imaging (fMRI), electroencephalography (EEG), biomarkers
![Pollack](/sites/default/files/styles/person_image/public/person-img/Pollack.png?h=fd5d399e&itok=yCij-nYT)
Molecularly targeted therapeutics for childhood and adult brain tumors and identifying and counteracting mechanisms of glioma treatment resistance.
![Prochownik](/sites/default/files/styles/person_image/public/person-img/Prochownik.jpeg?h=23512ece&itok=eL06lzKd)
Metabolic, molecular and biochemical changes in animal models of pediatric and adult liver cancers and how best to capitalize on these for therapeutic purposes
![Rich](/sites/default/files/styles/person_image/public/person-img/Rich.png?h=3f6b85e6&itok=zXmSvdw3)
The goals of the Rich Lab are to identify novel therapeutic paradigms in the treatment of advanced cancers, primarily malignant brain tumors, through the prism of stem cell biology to identify core regulatory pathways amenable to pharmacologic targeting.
![Richardson](/sites/default/files/styles/person_image/public/person-img/Richardson.png?h=9e04ce22&itok=uM56aOLY)
Immunometabolism at the host:pathogen interface using Staphylococcus aureus as a model pathogen
![Roberts](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%203.33.47%20PM.png?h=e79c4e16&itok=rcGQ4X0Z)
Our current work addresses preeclampsia and it pathophysiology in high and low resource
![Roman](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%203.37.18%20PM.png?h=2e881304&itok=x_2ZZDqM)
Understanding how endothelial cells integrate molecular and biomechanical signals to determine cell behavior during vascular development and disease
![Rosano](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2011.27.49%20AM.png?h=8cc1417f&itok=JHdX3D_n)
Brain adaptation, neuroepidemiological approaches to the causes, biomarkers and consequences of brain aging, advanced data reduction analyses
![Ross](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%203.39.35%20PM.png?h=35f2400f&itok=BvHuvx44)
Understanding the functional organization of spinal microcircuits using molecular genetic, electrophysiological, optogenetic & behavioral approaches
![Rossi](/sites/default/files/styles/person_image/public/person-img/Rossi.jpg?h=eb718353&itok=X-HO8XCY)
The living human retina and visual system in health and disease through the development and application of advanced ophthalmic imaging technologies
![Rothstein](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%203.40.02%20PM.png?h=63e20053&itok=w7iIsy57)
Immunoregulation: Focusing on regulatory and inflammatory B cells in transplant and autoimmune models, and their use as biomarkers in transplantation; as well as pathways by which regulatory T cells can be enhanced relative to Teffector cells
![Rubio](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%203.40.55%20PM.png?h=7d074ebc&itok=4bEMvwzg)
Understanding the functional organization of spinal microcircuits using molecular genetic, electrophysiological, optogenetic & behavioral approaches
![Sachdev](/sites/default/files/styles/person_image/public/person-img/Sachdev_Ulka_MD_Surgery_Passavant_7_2006.jpg?h=1364cbab&itok=li7mSQJR)
Endogenous danger signals promoting recovery following ischemic muscle injury; Inflammatory biomarkers in patients with venous disease
![Sadovsky](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.48.02%20AM.png?h=a8d96346&itok=54stIl5e)
Our lab focuses on molecular mechanisms underlying placental development and its function in supporting fetal growth and maternal-fetal communication.
![Anita Saraf](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-01%20at%209.54.12%20PM.png?h=5662f951&itok=8JwHT4kq)
My laboratory is interested in understanding congenital heart disease using translational models that relate clinical findings to in vitro systems, so as to further elucidate molecular and cellular mechanisms that contribute towards congenital heart disease. We use induced pluripotent stem cells (iPSCs) and gene editing to create clinically relevant biological models of congenital heart disease.
![Schopfer](/sites/default/files/styles/person_image/public/person-img/schopher.jpg?h=80a248ed&itok=fo_lpQF2)
Lipid signaling mediators associated with inflammation
![Daniella Schwartz](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-01%20at%209.58.53%20PM.png?h=52dcdd80&itok=Os0fpXzS)
My research program is focused on studying mechanisms of immune dysregulation by focusing on two areas: I work on the biology of interleukin 9 (IL-9) regulation/signaling in rheumatic diseases, and I study patients with rare monogenic diseases as “real world” models of immune dysregulation.
![Scott](/sites/default/files/styles/person_image/public/person-img/Scott_MelanieJ.jpg?h=66c0dfaa&itok=ao0OGsx8)
Innate immune responses to sterile injury and infection with a focus on inflammasome activation and immune activation by endogenous danger signals
![Shair](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.51.19%20AM.png?h=4ac8ac7d&itok=bRX5Fi2Z)
Studying Epstein-Barr virus molecular pathogenesis in the nasopharynx using 3-D cell air-liquid interface culture models.
![Shea](/sites/default/files/styles/person_image/public/person-img/Shea.png?h=fe19927d&itok=1mCqKQ15)
Dr. Shea utilizes microfluidic models and other flow-based assays to study hemostasis in the context of trauma and transfusion medicine. Dr. Shea is also interested in arterial thrombosis and thrombolysis.
![Shiva](/sites/default/files/styles/person_image/public/person-img/shiva.jpg?h=fba538fc&itok=po3r4Ih4)
Understanding the mechanisms by which mitochondrial function is regulated, particularly by reactive oxygen and nitrogen species and the contribution of these mechanisms to cardiovascular health and disease pathogenesis
![Shlomchik](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.53.18%20AM.png?h=9c2a3f18&itok=fbe4Ftpj)
My lab is interested in the establishment of long term B cell immunity and in pathogenesis of systemic autoimmune diseases and graft vs host disease.
![Shroff](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.55.48%20AM.png?h=f7c412a8&itok=5yLjpvtC)
Cardiac structure-function: contractile/regulatory proteins, post-translational regulation, dyssynchrony
![Shurin](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%203.55.18%20PM.png?h=b76a5d59&itok=YCHkT3VA)
Understanding of biological and clinical significance of tumor innervation and revealing neuroimmunological pathways controlling tumor spreading and metastasis formation
![Sunder Sims-Lucas](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-12-01%20at%2010.01.29%20PM.png?h=f162abda&itok=JH1fXx8S)
Dr. Sims-Lucas’ program focuses on acute kidney injury as well as the mechanisms that lead to predisposition to injury.
![Smithgall](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%204.14.18%20PM.png?h=c1be4c16&itok=gG3mKRoe)
Non-receptor protein-tyrosine kinase structure, regulation and signal transduction in cancer, AIDS, and embryonic stem cell biology
![Sorkin](/sites/default/files/styles/person_image/public/person-img/sorkin.jpg?h=98ae9c0d&itok=dHS0em1-)
Mechanisms and functional role of endocytic trafficking of EGF receptor in cancer cells and the dopamine transporter in the brain
![Sowa](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%204.15.17%20PM.png?h=b13abbb2&itok=WXUxWHOY)
Biomarker discovery, beneficial effects of mechanical loading, & implementation in targeted exercise therapies for musculoskeletal conditions
![St. Hilaire](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.59.26%20AM.png?h=78180179&itok=KWwLMdJN)
Characterizing the underlying pathobiology of vascular disease, concentrating on defining the mechanisms that drive vascular and valvular calcification and remodeling during aging and disease states
![Steinhauser](/sites/default/files/styles/person_image/public/person-img/Steinhauser.png?h=605a4ce4&itok=47bbBoeL)
We leverage molecular biology, human genetics, animal models, stable isotope tracers, imaging mass spectrometry, and human translational studies to discover cellular, molecular, and metabolic determinants of diseases of aging ranging from diabetes to cancer.
![Steinman](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%204.16.09%20PM.png?h=da6a7dca&itok=8x59fwzE)
Mechanisms of white blood cell differentiation & its inhibition in leukemias; Mechanisms of stem cell differentiation & growth control
![Stetten](/sites/default/files/styles/person_image/public/person-img/stetten.jpeg?h=e406cd53&itok=dmY7Aze_)
Image-guided surgery, medical image analysis, medical robotics, haptics, augmented reality, devices for visually impaired, music engineering
![Stolz](/sites/default/files/styles/person_image/public/person-img/Stolz.jpg?h=bf2d1fa4&itok=yIGuQWzV)
Angiogenesis and vascularization events in liver regeneration and remodeling
![Straub](/sites/default/files/styles/person_image/public/person-img/straub.jpg?h=b3472cd4&itok=cjEtZ8td)
The Straub laboratory investigates redox cell signaling mechanisms that control endothelial and smooth muscle biology in the microcirculation.
![Strick](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%204.17.57%20PM.png?h=c0d24452&itok=sEYObNJC)
The control of voluntary movement by the cerebral cortex; The functional organization of the basal ganglia and cerebellum; Unraveling the circuitry of the central nervous system
![Sun](/sites/default/files/styles/person_image/public/person-img/SUN_DANDAN_MD_PhD.jpg?h=9e04ce22&itok=8WuTclsH)
Understanding the role of ion transporter proteins (sodium-potassium-chloride cotransporter, sodium/proton exchanger, and sodium/calcium exchangers) in ionic dysregulation and neurodegeneration associated with stroke and hypoxic ischemic encephalopathy
![Sved](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%204.18.36%20PM.png?h=ba8a13d8&itok=GJjZROaL)
Central neural control of the autonomic nervous system and cardiovascular function; neurobiology of nicotine pharmacology
![Sweet](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2011.06.11%20AM.png?h=804a6a7f&itok=EH19QTlQ)
Loss and altered plasticity of auditory cortex synapses in schizophrenia; Mediators of vulnerability to psychosis in Alzheimer disease
![Tai](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.39.47%20AM.png?h=412c8c11&itok=CRG0qx-7)
Neural control of low urinary tract and neuromodulation of bladder dysfunction
![Bradley Taylor](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202024-05-29%20at%202.05.37%20PM.png?h=df95d887&itok=0tgAuMJ9)
We study the molecular neurobiology and pharmacology of chronic pain and substance misuse.
![Thomson](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.42.05%20AM.png?h=1782c05d&itok=U-gMlksr)
Regulation of the immune response; role of dendritic cells and T cells in tolerance induction; mechanism of action of novel immune suppressants
![Tzeng](/sites/default/files/styles/person_image/public/person-img/TZENG.jpg?h=5435c830&itok=lNoxTvEk)
Clinical applications of nitric oxide and carbon monoxide in the setting of vascular therapies
![Tzounopoulos](/sites/default/files/styles/person_image/public/person-img/thanos_new2.jpg?h=ce53a891&itok=z7xYAEIm)
We study synaptic mechanisms and their role during normal and pathological sensory processing (tinnitus).
![Urish](/sites/default/files/styles/person_image/public/person-img/URISH.jpg?h=cefb9de9&itok=5oB9h84o)
The focus of the Urish laboratory is on understanding implant biofilm dynamics during an infection and identifying new treatment strategies.
![Van Houten](/sites/default/files/styles/person_image/public/person-img/houten.jpg?h=869d4a80&itok=KqxHsSgt)
Repair of DNA damage in nuclear and mitochondrial genomes; Structure and function of nucleotide excision repair proteins
![Daria Van Tyne Picture](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-05-30%20at%203.02.50%20PM.png?h=22b8a25c&itok=zTVjiqVl)
The Van Tyne Lab studies how bacteria evolve to become superbugs, using comparative genomics and functional analysis. Our research falls into two main areas. First, we work to understand how bacteria evolve during human infection to resist antibiotics and host immune defenses. We sequence bacterial strains from human infections and use functional genomics to identify and characterize novel resistance mechanisms. These include the ability of bacteria to resist the host immune system, or to persist in the face of antibiotic pressure. Second, we help develop new approaches to treat resistant bacterial infections more effectively. We help characterize new types of antibiotics, and establish how novel compounds kill bacteria. We are also exploring how bacteriophages could be developed into next-generation antibacterials.
![Vazquez](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.17.19%20AM.png?h=eef2b3d4&itok=LMyfNTUQ)
Brain imaging of neuronal, metabolic and vascular function and dysfunction
![Villanueva](/sites/default/files/styles/person_image/public/person-img/Villanueva.jpg?h=300bf1e0&itok=5C47Kd2a)
The development of medical diagnostic and therapeutic strategies that are based on ultrasound and ultrasound contrast agents (microbubbles)
![Visweswaran](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.24.41%20AM.png?h=74c634ee&itok=eBmfpGMi)
Computer-aided diagnosis and patient-specific prediction, genomic and precision medicine, clinical decision support, research data warehouse
![Nam Vo Picture](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-05-30%20at%202.37.57%20PM.png?h=0757fe7a&itok=MKldV1iB)
Dr Vo’s research program aims at studying the biology of aging of the spine and its contribution to low back pain. His research focus areas include: 1) interaction of autophagy and cellular senescence in spinal aging, 2) lactate metabolism and epigenetic regulation in spinal aging, 3) development of therapeutic interventions, including senolytics and gene therapy, for treating age-related spine degeneration and low back pain, and 4) Deep phenotyping of chronic low back pain through biomarker profiling.
![Vockley](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.27.22%20AM.png?h=98850546&itok=AgFmIk9O)
Structure/function relationship in the acyl-CoA dehydrogenases (ACDs)
![Vodovotz](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.33.35%20AM.png?h=93597c50&itok=Wj8I8CaZ)
My long-term research goals are to obtain high-dimensional, dynamic data on the etiology and progression of various inflammatory processes and diseases in samples derived from cells, animals, and people; to create computational models based on these data as well as on key principles of immunology; and to modulate the inflammatory response in an optimal spatial, temporal, and individual- / disease-specific manner.
![Vorp](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.36.49%20AM.png?h=1096d7cf&itok=W0dfcpH1)
Vascular bioengineering in the context of vascular tissue engineering, aortic aneurysm, and regenerative medicine
![Wagner](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-08-02%20at%204.29.34%20PM.png?h=6602a7dd&itok=gXcdJsNM)
Cardiovascular engineering with projects that address medical device biocompatibility and design, tissue engineering, and imaging
![Walker](/sites/default/files/styles/person_image/public/person-img/Walker-William-PhD-10-26-2016.jpeg?h=d66bc94b&itok=yN1Qlxv2)
Regulation of mammalian sperm
![Kurt Weiss](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%209.52.45%20AM.png?h=5c287c27&itok=i4gKbgGd)
Basic science laboratory dedicated to the study of sarcomas--cancerous tumors that arise in the musculoskeletal tissues
![Ora Weisz](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%209.57.41%20AM.png?h=cfcba1f3&itok=PQu2R2w6)
Regulation of protein traffic in polarized epithelial cells
![Wells](/sites/default/files/styles/person_image/public/person-img/wells.jpeg?h=916efa53&itok=PRrNzKUI)
Integrative biology of wound healing and tumor metastasis, from molecules and cells through tissues and animals to humans
![Wendell](/sites/default/files/styles/person_image/public/person-img/Wendell.png?h=013cd1e9&itok=WasqvKYT)
Investigates the signaling of electrophilic fatty acids in transformed stable cell lines while collaborating with clinicians to study the formation and signaling of electrophilic fatty acids in healthy controls, mild to moderate, and severe asthmatic subjects
![Wenzel](/sites/default/files/styles/person_image/public/person-img/Wenzel.jpg?h=d21acc70&itok=JLN-WeDI)
Focuses on asthma phenotypes and the molecular mechanisms, particularly in the airway epithelium that control them
![John Williams](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.07.59%20AM.png?h=de5eee25&itok=Fgd6Pibr)
The cell entry, immunity, and pathogenesis of human metapneumovirus (HMPV)
![Peter Wipf](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-13%20at%2010.10.09%20AM.png?h=7bdb67d8&itok=CI6AF013)
Drug discovery and drug development, employing organic synthesis, medicinal chemistry and molecular modeling to develop new therapeutic agents for cancer and neurodegenerative diseases in a highly collaborative environment
![Yan Xu](/sites/default/files/styles/person_image/public/person-img/Screen%20Shot%202023-09-11%20at%2011.27.39%20AM.png?h=b47bd42c&itok=S7EgY65v)
Designed receptors as therapeutic targets for pain; Mechanisms of low-affinity drug action; Mapping of unconscious brain; Stem cell therapy for stroke
![Yanowitz](/sites/default/files/styles/person_image/public/person-img/Yanowitz.jpg?h=e51507b7&itok=XzzwJzB8)
Pathways that control the maintenance of genome integrity across generations using the nematode Caenorhabditis elegans
![Zuckerbraun](/sites/default/files/styles/person_image/public/person-img/ZUCKERBRAUN.jpg?h=9773c05e&itok=Lvee-TJ2)
Mitochondrial and metabolic responses to trauma and sepsis ad their influence on inflammation and immunity