This list of affiliated investigators can help you identify potential research mentors at the University of Pittsburgh. PSTP students can, and do, work with mentors not on this list, but the investigators featured below have expressed interest in hosting PSTP students in their laboratories
Elias Aizenman, PhD
Cellular and Molecular Basis of Neurodegeneration
Howard Aizenstein, MD, PhD
Cellular and Molecular Basis of Neurodegeneration
Zandrea Ambrose, PhD
HIV infection and therapeutics
Carolyn Anderson, PhD
The development of metal-based radiopharmaceuticals for diagnosis and targeted radiotherapy of cancer and other diseases
Gerard Apodaca, PhD
Endocytic pathways and stretch-regulated endocytosis/exocytosis in bladder.
Stephen Badylak, MD, PhD, DVM
Tissue Engineering and Regenerative Medicine, emphasis upon clinical application; cell:biomaterial interactions; epimorphic regeneration in mammals
Ivet Bahar, PhD
Biomolecular systems dynamics; computer-aided drug discovery; network models for protein-protein interactions
Christopher Bakkenist, PhD
Identify phosphorylations, dephosphorylations and acetylations that regulate ATM activity in vivo.
Carlton Bates, MD
Role of FGF Receptors in the Developing Kidney, Genetic Model of Urogenital Development and Obstruction,and Role of fibroblast growth factor receptors (Fgfrs) in embryonic kidney development using conditional knockout mouse models
Aaron Batista, PhD
Neurophysiology of sensory-motor coordination, brain-machine interfaces.
Hülya Bayir, MD
Clinical lipidomics and oxidative lipidomics; Imaging mass spectrometry; Redox mechanisms of mitochondrial dysfunction and neuronal death
Takis Benos, PhD
Multi-scale computational modeling of omics and clinical data to identify the causes of disease phenotypes and therapy outcomes
Sarah Berman, MD, PhD
Role of mitochondrial dynamics in Parkinson’s disease and other neurodegenerative diseases.
Kara Bernstein, PhD
Repair of DNA damage is crucial to prevent mutations observed in cancer. Using live cell imaging, we study how double-strand breaks are repaired.
Timothy Billiar, MD
The Billiar Lab focuses on the immune responses to acute systemic stresses of major clinical relevance including trauma and surgical sepsis
Robert Binder, PhD
The mechanisms of cross-priming of antigens during immune responses to cancer, viruses and autoimmunity.
Jennifer Bomberger, PhD
Understanding the molecular mechanisms for viral-bacterial synergy in the lungs of chronic lung disease patients
Lisa Borghesi , PhD
Demand adapted hematopoiesis in infection and inflammation.
Grant Bullock, MD, PhD
The molecular mechanisms of anemia and how iron deficiency and mitochondrial metabolic defects affect red blood cell production
Timothy F. Burns, MD, PhD
Development of targeted therapies for KRAS mutant NSCLC; Reactivation of OIS and apoptosis; Mechanisms of acquired resistance to targeted agents
Lisa Butterfield, PhD
The Butterfield lab focuses on cross-talk between tumor antigens and the immune system in melanoma and hepatocellular cancer (HCC) patients
Craig Byersdorfer, MD, PhD
The Byersdorfer lab seeks a deeper understanding of In vivo T cell metabolism, in order to develop therapies that separate pathologic effects from physiologic and beneficial responses following allogeneic blood and marrow transplantation.
Guillermo Calero, MD, PhD
Reconstitution of multi-protein complexes (MPCs) for biochemical and X-ray crystallographic studies
Clifton W. Callaway, MD, PhD
Improving recovery from brain injury after cardiac arrest
Geetha Chalasani, MD
Understanding how memory T cells are generated in transplantation
Stephen Chan, MD, PhD
Basic science and translational research studying the molecular mechanisms of pulmonary vascular disease and pulmonary hypertension
Yuan Chang, MD
The study of human tumor viruses
Charleen Chu, MD, PhD
Redox signaling & autophagy in neuroprotection and neurodegeneration; mitochondrial phosphoproteomics; genetic & toxin models of Parkinson’s disease
Nathan Clark, PhD
Comparative genomics to determine the genetic regions that control medically important phenotypes, ranging from vision to oxidative stress
Paula Clemens, MD
Models of muscle disease causing muscular dystrophy and muscle atrophy. Translational research for treatment of muscle disease.
Gilles Clermont, MD
Big data analytics, predictive modeling, and dynamic modeling of disease
Lan Coffman, MD, PhD
Stomal Interactions critical to the survival, growth, and spread of ovarian cancer.
Greg M. Cooper, PhD
Developing therapeutics to control bone growth and healing in pediatric patients with craniofacial malformations
Carolyn Coyne, PhD
Virology, immunology, and cell biology to dissect various aspects of host virus interactions, with a particular focus on polarized cell types.
X. Tracy Cui, PhD
The intersection of neural engineering and biomaterials with specific focus on neural electrode-tissue interface, neural tissue engineering, biosensor and drug delivery.
Lance Davidson, PhD
Our group combines experimental and theoretical approaches to reverse-engineer the inherently mechanical processes of cell and tissue development.
Brian Davis, PhD
Cellular and molecular mechanisms of central and peripheral nervous system development and plasticity
Marie DeFrances, MD, PhD
HGF-MET-PI3K signaling in liver development, growth, regeneration and cancer. She has identified a novel regulator of the catalytic subunit of PI3K (p110) called PI3K interacting protein 1 (PIK3IP1)
Donald DeFranco, PhD
Steroid hormone action in neural stem cells and cancer
Greg Delgoffe, PhD
The metabolic regulation of T cell function, with a specific focus of those T cells that infiltrate the nutrient-poor tumor microenvironment.
Neal DeLuca, PhD
HSV gene expression in productive and persistent infections
Terence Dermody, MDResearch Areas Research Summary
Research in the Dermody laboratory focuses on the molecular mechanisms of Mammalian Orthoreovirus (reovirus) and Chikungunya virus infections
Thomas Diacovo, MDResearch Areas Research Summary
Role of class I PI3Ks in innate and adaptive immunity. Thrombosis prevention in neonates preoperatively
Alexandre Dombrovski, MD
Decision processes in late-life suicidal behavior and in borderline personality
Chris Donnelly, PhD
The molecular pathogenesis of neurodegeneration and aging
Umamahefwar Duvvuri, MD, PhD
The molecular landscape of head and neck cancers; tying this to technical innovations that improve surgical care for these patients.
Jonathan D’Cunha, MD, PhD
Molecular mechanisms of non-small cell lung cancer tumorigenesis
Louis Falo, MD, PhD
Developing a better understanding of cutaneous biology and skin immune function, and leveraging that evolving understanding to develop new skin-targeted strategies to modulate local and systemic immune responses
William Federspiel, PhD
Respiratory assist and blood processing devices for critical care medicine. Cardiovascular and pulmonary transport phenomena.
Fabio Ferrarelli, MD, PhD
The neurobiology of schizophrenia and neurophysiological abnormalities during wakefulness and sleep in early course psychosis
Robert Ferris, MD, PhD
Mechanisms of immune escape and clinical translation to therapeutic cancer immunotherapy trials
Toren Finkel, MD, PhD
Intersection of mitochondrial function, metabolism and aging
Kenneth N. Fish, PhD
Functional consequences of altered connectivity in schizophrenia; the early secretory pathway’s role in neurodevelopment and synaptogenesis
Joanne Flynn, PhD
Immunology and Pathogenesis of Tuberculosis.
Bruce Freeman, PhD
The production and signal transduction properties of oxidizing and free radical mediators in metabolic, respiratory and cardiovascular diseases.
Zach Freyberg, MD, PhD
Dopaminergic signal transduction in the central nervous system, Dopamine role in regulating peripheral pancreatic insulin secretion
Robert Friedlander, MD
The study of the basic mechanisms of apoptosis, as mediated by the caspase apoptotic family in neurologic diseases
James Funderburgh, PhD
Stem cells and stem cell therapy, wound healing, tissue regeneration, biological roles of extracellular matrix
Mark Gladwin, MD
Biophysical and biochemical measures and mouse models to investigate a novel therapeutic intervention for carbon monoxide poisoning
Anthony Grace, PhD
Neurophysiology of basal ganglia system related to psychiatric disorders.
Timothy Hand, PhD
Understand the causes of diseases with disruptions between immune system and the microbiota, such as Crohn’s Disease and Environmental Enteropathy.
Teresa Hastings, PhD
Oxidative mechanisms associated with neurodegeneration.
Jackie Ho, MD
Chronic kidney disease (CKD) is a growing public health burden that results in significant morbidity and increased risk of mortality for individual patients.
Sohail Husain, MD
Pathogenesis of pancreatic injury at the epigenetic level; Drug-induced pancreatitis.
Edwin K. Jackson, PhD
The biochemistry, molecular/cell biology, and physiology/pharmacology of adenosine
Jon Johnson, PhD
The Johnson lab studies the physiology, biophysics, structure, pharmacology, and regulation of glutamate receptors
Lawrence Kane, PhD
Signal Transduction; The role of the Akt kinase in NF-kB and T cell activation; Role of TIM proteins in T cell activation.
Daniel Kaplan, MD, PhD
Role for nerves in the skin as modulators of immune responses.
Ata Murat Kaynar, MD, MPH
Long-term outcomes following sepsis using a Drosophila as well as murine model of sepsis
Erin Kershaw, MD
The role of intracellular lipid metabolism and adipose tissue biology in normal metabolism and disease using basic and translational approaches
Kang Kim, PhD
Develop & translate state of the art noninvasive imaging technologies to improve disease diagnosis, guide therapy, and evaluate therapeutic efficacy
Thomas Kleyman, MD
Cellular, structural and molecular studies of epithelial ion channels
Eric Lagasse, PhD, PharmD
Our research is focused primarily on stem cell biology and cell-based therapy for a variety of diseases including cancer and organ failure.
Fadi Lakkis, MD
Innate and adaptive immune response to transplanted organs and the mechanisms of transplantation tolerance.
Adrian Lee, PhD
Molecular profiling (genomic, transcriptomic, proteomic) of women’s cancers, mouse modeling, and predictive biomarkers for targeted therapy
Janet Lee, MD
Host susceptibility to lung injury and the factors that promote persistence of inflammation
David Lewis, MD
Functional architecture of the prefrontal cortex and schizophrenia.
Philana Lin, MD, MSC
Our lab is focused on the host protective immune responses to M. tuberculosis, a major factor in outcome of infection.
Steven Little, PhD
Drug Delivery, Biomimetics, Immunotherapeutics, Tissue Engineering, Biomaterials, Synthetic Systems
Youhua Liu, PhD
The cellular and molecular pathways leading to chronic renal fibrosis, and exploring novel strategies for therapeutic interventions
Peter Lucas, MD, PhD
The relationship between chronic inflammation and the development of vascular, metabolic, and neoplastic diseases
Beatriz Luna, PhD
Brain basis of cognitive maturation through adolescence to adulthood.
Rama Mallampalli, MD
Pulmonary molecular & cell biology as it relates to acute lung injury (ALI) & the mechanisms of sepsis
Melissa Mann, PhD
Molecular Regulation of Genomic Imprinting in Gametes and Early Embryos
Mioara Manole, MD
Vascular pathways involved in cerebral vascular dysregulation and therapeutic strategies that improve neurological outcome after pediatric asphyxial cardiac arrest
Kacey G. Marra, PhD
Tissue engineering (peripheral nerve and soft tissue), wound healing, and adipose stem cell therapies
Wendy Mars, PhD
Understanding how cytokines and proteases controlling normal liver growth become deviant, leading to the development of cirrhosis and liver cancer
Linda McAllister-Lucas, MD, PhD
Mechanisms by which dysregulated intracellular signaling promotes inflammation and neoplasia
Colleen Mcclung, PhD
We are interested in the molecular mechanisms of psychiatric disorders with a particular focus on the role of the circadian clock in these disorders
John Mellors, MD
Mechanisms of HIV-1 persistence at the single cell level and evaluating strategies to cure HIV-1 infection, including latency reversing agents, monoclonal antibodies, cellular immunotherapy and therapeutic vaccines.
Stephen D. Meriney, PhD
Focuses on mechanisms of synaptic plasticity in the neuromuscular system in both normal and disease conditions
George Michalopoulos, MD, PhD
Liver regeneration and carcinogenesis, exploring the effects of growth factors and associated signaling pathways
Pam Moalli, MD, PhD
Use of novel regenerative materials in repair of pelvic organ prolapse and urinary incontinence.
Satdarshan (Paul) Monga, MD
Aimed at elucidating the cellular and molecular mechanisms of liver pathophysiology
Patrick S. Moore, MD, MPH
The study of human tumor viruses
Ana Mora, MD
The pathogenic mechanisms of Idiopathic Pulmonary Fibrosis (IPF) in aging; Mitochondrial-targeted therapies in animal models of lung fibrosis
Penelope Morel, MD
Autoimmunity & the control of T cell immune responses; Systems biology approaches to immune response to infectious organisms
Adrian Morelli, MD, PhD
The role of donor- and recipient-derived antigen-presenting cells (i.e. dendritic cells) and extracellular vesicles (i.e. exosomes, microvesicles) during allo-sensitization, graft rejection, and induction of donor-specific immunosuppression / tolerance, following transplantation
Alison Morris, MD, MS
HIV-associated lung disease; HIV-associated emphysema; Role of Pneumocystis in COPD
Radhika Muzumdar, MD
GH, insulin-like growth factors and a novel mitochondria-associated peptide on glucose homeostasis, energy metabolism, cardiovascular health and aging.
Matthew Neal, MD
The mechanisms of hemostasis and coagulation following trauma and hemorrhagic shock.
Vishwajit Nimgaonkar, PhD
Genetics of schizophrenia/bipolar disorder; functional genomics using induced pluripotent stem cell (iPSC) based models; gene/environment interactions
Robert O'Doherty, PhD
The association between states of over nutrition and resulting metabolic disturbances, most notably obesity, NAFLD, and Type 2 Diabetes
Steffi Oesterreich, PhD
Hormone response and treatment resistance in breast and ovarian cancer, including the analysis of aberrant genetic and epigenetic changes
Patricia Lynn Opresko, PhD
Mechanisms for preserving telomeres in healthy cells to delay aging-related diseases including cancer, or that conversely deplete telomeres in cancer cells to stop their proliferation
Kyle Orwig, PhD
Spermatogonial stem cells (SSCs) and male germ lineage development
Tim Oury, MD, PhD
Oxidative mechanisms of pulmonary fibrosis, acute lung injury, inflammation, and pneumonia. The laboratory also studies the role of RAGE in the lung
Quasar Padiath, MDBS, PhD
Molecular mechanisms underlying various neurological disorders using human genetic approaches as well as research on animal and cell culture models
Patrick Pagano, PhD
NADPH oxidase (Nox) & reactive oxygen species in signaling, vascular dysfunction and cardiopulmonary disease; Nox drug therapy development
Udai Pandey, PhD
Molecular mechanisms of amyotrophic lateral sclerosis (ALS)
Marta Pecina, MD, PhD
Neuroimaging biomarkers of antidepressant treatment response in humans. Molecular bases of depression.
Mary Phillips, MD
Identification of neural correlates that underlie the symptoms of specific abnormalities in emotion processing in people with mood disorders
Edward Prochownik, MD, PhD
Metabolic, molecular and biochemical changes in animal models of pediatric and adult liver cancers and how best to capitalize on these for therapeutic purposes
Anthony Richardson, PhD
Immunometabolism at the host:pathogen interface using Staphylococcus aureus as a model pathogen
R. Mark Richardson, MD, PhD
Cortical and subcortical neurophysiology in patients undergoing surgery for epilepsy and movement disorders
James Roberts, MD
Our current work addresses preeclampsia and it pathophysiology in high and low resource
Beth Roman, PhD
Understanding how endothelial cells integrate molecular and biomechanical signals to determine cell behavior during vascular development and disease
Caterina Rosano, MD, MPH
Brain adaptation, neuroepidemiological approaches to the causes, biomarkers and consequences of brain aging, advanced data reduction analyses
Sarah Ross, PhD
Understanding the functional organization of spinal microcircuits using molecular genetic, electrophysiological, optogenetic & behavioral approaches
David Rothstein, MD
Immunoregulation: Focusing on regulatory and inflammatory B cells in transplant and autoimmune models, and their use as biomarkers in transplantation; as well as pathways by which regulatory T cells can be enhanced relative to Teffector cells
Maria Rubio, MD, PhD
Understanding the functional organization of spinal microcircuits using molecular genetic, electrophysiological, optogenetic & behavioral approaches
Ulka Sachdev, MD
Endogenous danger signals promoting recovery following ischemic muscle injury; inflammatory biomarkers in patients with venous disease.
Yoel Sadovsky, MD
Our lab focuses on molecular mechanisms underlying placental development and its function in supporting fetal growth and maternal-fetal communication
Saumendra Sarkar, PhD
Two related aspects involved in interferon production in the context of infectious disease and cancer: Modulation of IFN induction during RNA and DNA virus infections; Mechanisms and consequences of interferon induction in specific tumors.
Francisco Schopfer, PhD
Lipid signaling mediators associated with inflammation
Melanie Scott, MD, PhD
Innate immune responses to sterile injury and infection with a focus on inflammasome activation and immune activation by endogenous danger signals
Sruti Shiva, PhD
Understanding the mechanisms by which mitochondrial function is regulated, particularly by reactive oxygen and nitrogen species and the contribution of these mechanisms to cardiovascular health and disease pathogenesis
Mark Shlomchik, MD, PhD
My lab is interested in the establishment of long term B cell immunity and in pathogenesis of systemic autoimmune diseases and graft vs host disease
Sanjeev Shroff, PhD
Cardiac structure-function: contractile/regulatory proteins, post-translational regulation, dyssynchrony
Michael Shurin, MD, PhD
Understanding of biological and clinical significance of tumor innervation and revealing neuroimmunological pathways controlling tumor spreading and metastasis formation
Marc Simon, MD, MS, FACC
Study of right ventricular structural and functional adaptation to pressure overload in pulmonary hypertension and heart failure
Thomas Smithgall, PhD
Non-receptor protein-tyrosine kinase structure, regulation and signal transduction in cancer, AIDS, and embryonic stem cell biology
Alexander Sorkin, PhD
Mechanisms and functional role of endocytic trafficking of EGF receptor in cancer cells and the dopamine transporter in the brain
Gwendolyn Sowa, MD, PhD
Biomarker discovery, beneficial effects of mechanical loading, & implementation in targeted exercise therapies for musculoskeletal conditions
Cynthia St. Hilaire, PhD
Characterizing the underlying pathobiology of vascular disease, concentrating on defining the mechanisms that drive vascular and valvular calcification and remodeling during aging and disease states
Richard Steinman, MD, PhD
Mechanisms of white blood cell differentiation & its inhibition in leukemias; Mechanisms of stem cell differentiation & growth control
George Stetten, MD, PhD
Image-guided surgery, medical image analysis, medical robotics, haptics, augmented reality, devices for visually impaired, music engineering
Donna Stolz, PhD
Angiogenesis and vascularization events in liver regeneration and remodeling
Adam Straub, PhD
The Straub laboratory investigates redox cell signaling mechanisms that control endothelial and smooth muscle biology in the microcirculation.
Peter Strick, PhD
The control of voluntary movement by the cerebral cortex; the functional organization of the basal ganglia and cerebellum; unraveling the circuitry of the central nervous system.
Dandan Sun, MD, PhD
Understanding the role of ion transporter proteins (sodium-potassium-chloride cotransporter, sodium/proton exchanger, and sodium/calcium exchangers) in ionic dysregulation and neurodegeneration associated with stroke and hypoxic ischemic encephalopathy.
Alan Sved, PhD
Central neural control of the autonomic nervous system and cardiovascular function; neurobiology of nicotine pharmacology
Robert Sweet, MD
Loss and altered plasticity of auditory cortex synapses in schizophrenia; mediators of vulnerability to psychosis in Alzheimer disease.
Changfeng Tai, PhD
Neural control of low urinary tract and neuromodulation of bladder dysfunction
Angus Thomson, PhD, DS.c.
Regulation of the immune response; role of dendritic cells and T cells in tolerance induction; mechanism of action of novel immune suppressants
Allan Tsung, MD
Innate immunity and the damage-associated molecular pattern (DAMP) danger response, specifically, the role of DAMPs and pattern recognition receptors in injury-induced inflammation and tumorigenesis of primary and metastatic liver cancer
Edith Tzeng, MD
Clinical applications of nitric oxide and carbon monoxide in the setting of vascular therapies
Thanos Tzounopoulos, PhD
We study synaptic mechanisms and their role during normal and pathological sensory processing (tinnitus).
Ken Urish, MD, PhD
The focus of the Urish laboratory is on understanding implant biofilm dynamics during an infection and identifying new treatment strategies.
Patrick van der Wel, PhD
Misfolding, aggregation and amyloid formation in disease; membrane protein structure and lipid interactions; solid-state NMR spectroscopy; biophysics
Ben Van Houten, PhD
Repair of DNA damage in nuclear and mitochondrial genomes; Structure and function of nucleotide excision repair proteins.
Flordeliza Villanueva, MD
The development of medical diagnostic and therapeutic strategies that are based on ultrasound and ultrasound contrast agents (microbubbles).
Shyam Visweswaran, MD, PhD
Computer-aided diagnosis and patient-specific prediction, genomic and precision medicine, clinical decision support, research data warehouse
Jerry Vockley, MD, PhD
Structure/function relationship in the acyl-CoA dehydrogenases (ACDs)
David Volk, MD, PhD
Abnormalities that underlie the devastating clinical features of schizophrenia using molecular biology techniques
David Vorp, PhD
Vascular bioengineering in the context of vascular tissue engineering, aortic aneurysm, and regenerative medicine
William Wagner, PhD
Cardiovascular engineering with projects that address medical device biocompatibility and design, tissue engineering, and imaging.
William Walker, PhD
Regulation of mammalian sperm
Kurt Weiss, MD
Basic science laboratory dedicated to the study of sarcomas--cancerous tumors that arise in the musculoskeletal tissues.
Ora Weisz, PhD
Regulation of protein traffic in polarized epithelial cells
Alan Wells, MD, DMS
Integrative biology of wound healing and tumor metastasis, from molecules and cells through tissues and animals to humans
Sally Wenzel, MD
Focuses on asthma phenotypes and the molecular mechanisms, particularly in the airway epithelium that control them
Clayton Wiley, MD, PhD
Pathogenesis of Neuroinflammation, Neurodegeneration and Neurovirology
John Williams, MD
The cell entry, immunity, and pathogenesis of human metapneumovirus (HMPV)
Peter Wipf, PhD
Drug discovery and drug development, employing organic synthesis, medicinal chemistry and molecular modeling to develop new therapeutic agents for cancer and neurodegenerative diseases in a highly collaborative environment
Yan Xu, PhD
Designed receptors as therapeutic targets for pain; mechanisms of low-affinity drug action; mapping of unconscious brain; stem cell therapy for stroke
Judith Yanowitz, PhD
Pathways that control the maintenance of genome integrity across generations using the nematode Caenorhabditis elegans
Lin Zhang, PhD
Genetic basis of differential sensitivity to anticancer drugs; genetic alterations that cause drug resistance; mechanisms of drug-induced apoptosis