Undergraduate Degree: BS
Undergraduate Degree Year: 2008
Undergraduate Institution: Lehigh University
Undergraduate Major: Chemical Engineering
Masters Degree Institution: Cornell University
Masters Degree Year: 2009
Year in Program: MS3
Research Advisor First Name: Fadi
Research Advisor Last Name: Lakkis
Research Title/Research Topic: Role of dendritic cell cross-dressing in allograft rejection
Current Research Description: Preliminary results suggest that cross-dressing by recipient dendritic cells (DC), a process by which whole pieces of cell membrane are acquired by DC and expressed unaltered on the DC surface, may be important in the activation of antigen-specific T cells and subsequent allograft rejection. This project will characterize the prevalence and physiological importance of cross-dressing in mouse models of kidney transplantation.
Student Committee Participation
Student Committee Involvement:
Grant Support Information:
1) Hughes, A.D. and King, M.R. (2010). “Use of naturally occurring halloysite nanotubes for enhanced capture of flowing cells,” Langmuir 26:12155-64.
2) Hughes, A.D. and King, M.R. (2012). “Nanobiotechnology for the capture and manipulation of circulating tumor cells,” Wiley Interdisciplinary Reviews in Nanomedicine and Nanobiotechnology 4:291-309.
3) Hughes, A.D., Mattison, J., Western, L.T., Powderly, J.D., Greene, B.T., King, M.R. (2012). “Microtube device for selectin-mediated capture of viable circulating tumor cells from blood,” Clinical Chemistry 58:846-53.
4) Hughes, A.D., Mattison, J., Powderly, J.D., Greene, B.T., King, M.R. (2012). “Rapid isolation of viable circulating tumor cells from patient samples,” Journal of Visualized Experiments Jun 15;(64):e4248
5) Greene, B.T.*, Hughes, A.D.*, King, M.R. (2012). “Circulating tumor cells: the substrate of personalized medicine?” Frontiers in Oncology 2:69.
6) King, M.R. and Hughes, A.D. “Fluid Flow Device Containing Nanotubes and Method for Cell Trafficking Using Same.” U.S. Patent Application No. 13/500,476, filed April 5, 2012.
7) Hughes, A.D.*, Marshall, J.R.*, Keller, E., Powderly, J.D., Greene, B.T., King, M.R. (2014). “Differential drug responses of circulating tumor cells within patient blood,” Cancer Letters 352(1):28-35.