Undergraduate Degree: BS
Undergraduate Degree Year: 2011
Undergraduate Institution: Northeastern University
Undergraduate Major: Behavioral Neuroscience
Year in Program: MS4
Graduate Program: Bioengineering
Research Advisor First Name: Kacey G.
Research Advisor Last Name: Marra
Research Title/Research Topic: Project 1: Evaluation of a Poloxamer Hydrogel for the Delivery of Adipose-Derived Stem Cells in the Context of Peripheral Nerve Regeneration; project 2: Differential Effects of Transcription Factor Egr1 Across Cell Lines and Commitment Status: Analysis in
Current Research Description: Project 1: This translational project aims to improve therapeutic outcomes in peripheral nerve injury and repair. We are using a rat model of nerve injury to investigate an improved delivery system - a poloxamer hydrogel - for the delivery of Adipose-derived stem cells to the site of nerve repair.; project 2: This basic science project aims to better understand the role of Egr1, a zinc-finger transcription factor, in commitment to the adipogenic lineage. We are investigating changes in gene expression programs and differentiation potential in the 3T3-L1 cell line (murine pre-adiopocytes) with the transient overexpression of Egr1.
Student Committee Participation
Student Committee Involvement:
Grant Support Information:
PEER REVIEWED PUBLICATIONS
Kerenyi, Marc A., et al. "Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation." eLife 2 (2013).
NON-PEER REVIEWED PUBLICATIONS
Kassandra O’Brien, Jacqueline Biley, Emmanuelle Havis, Isaac James, Sheri Wang, Wesley Sivak, Kacey Marra, J. Peter Rubin. Evaluation of a Poloxamer Hydrogel for the Delivery of Adipose-Derived Stem Cells in the Context of Peripheral Nerve Regeneration. Annual Meeting of the International Federation for Adipose Therapeutics and Science (IFATS). New Orleans, LA. November 2015.
"Alterations in Dopamine and Dopamine D2 Receptors Correlate with Adolescent, Anabolic Androgenic Steroid Treated Hamsters,” November 2007, N.E.U.R.O.N Conference, Boston, MA, K.L. O’Brien, J.J. Schwartzer, L.A. Ricci, R.H. Melloni
"Assay Optimization and Validation for the Characterization of Gene Expression Changes in Key Inflammatory Cytokines at the Neural Electrode-Tissue Interface," August 2013, PSTP Symposium, Pittsburgh, PA. K OBrien, J Hanner, C Kolarcik, XT Cui.
Tieman Research Award, November 2007