Daniel Ludwig


Education
Undergraduate Degree: Bachelor of Science
Undergraduate Degree Year: 2009
Undergraduate Institution: Brown University
Undergraduate Major: Biomedical Engineering


Academic Status
Year in Program: A
Graduate Program: Cardiology
Research Advisor First Name:
Research Advisor Last Name:
Research Title/Research Topic: Cardiac Resynchronization Therapy for the Reduction of Post-Infarction Adverse Remodeling
Current Research Description: An estimated 865,000 Americans will suffer from a myocardial infarction (MI) each year, with a nationwide prevalence of prior MI at nearly eight million. Ischemia or infarction causes functional abnormalities including a reduction in peak systolic strain that correlates with the extent of the obstruction or infarct size, and reduced strain in myocardial regions adjacent to the infarction relative to remote regions. These functional abnormalities produce a mechanically dyssynchronous contraction, leading to focal elevations in wall stress which may contribute to pathologic functional and geometric changes known as adverse remodeling. Previous work at the University of Pittsburgh in a rabbit model of infarction suggests that cardiac resynchronization therapy is protective against adverse remodeling. We hypothesize that cardiac resynchronization therapy applied shortly after infarction in an animal model will decrease adverse remodeling by reducing mechanical dyssynchrony.


Honors
Undergraduate Honors: Undergraduate Honors: USSP Fellowship, University of Pennsylvania, Division of Gastroenterology (2007), RI-EPSCoR Fellowship (2008), Best Environmental Project, iGEM Competition (2008), Tau Beta Pi (2008), Sigma Xi (2009), BMEidea Competition Winner, Third Prize (2009), Sc.B. Magna cum Laude with Departmental Honors (2009), Brown University Outstanding Senior Award in Biomedical Engineering (2009). Medical School Honors: Morris H. and Gertrude M. Harris Foundation Scholarship (2010); Pitt IEE Big Idea Competition Winner, Runner-up (2012), First Prize (2011), Second Prize (2010). Pitt OED Michael G. Wells Student Entrepreneurship Competition, Finalist (2011). American Society of Nuclear Cardiology Astellas Travel Award and Young Investigator Award, Runner-up (2012).



Student Committee Participation
Student Committee Involvement:
Interviewing, Hosting

Grant Support
Grant Support Information: Submitted to American Heart Association, May 2011

Publications
PEER REVIEWED PUBLICATIONS:

1. Rhieu SY, Ludwig DR, Siu VS, Palmore GTR. Direct electrochemistry of cytochrome P450 27B1 in surfactant films. Electrochem Commun, 2009. 11(10): 1857-60.

2. Schelbert EB, Testa SM, Meier CG, Ceyrolles WJ, Levenson JE, Blair AJ, Kellman P, Jones BL, Ludwig DR, Schwartzman D, Shroff SG, Wong TC. Myocardial Extravascular Extracellular Volume Fraction Measurement by Gadolinium Cardiovascular Magnetic Resonance in Humans: Slow Infusion versus Bolus. J Cardiovasc Magn Reson, 2011.13:16.

3. Ludwig DR, Friehling M, Schwartzman D, Saba S, Follansbee WP, Soman P, On the Importance of Image Gating for the Assay of Left Ventricular Mechanical Dyssynchrony using SPECT. J Nucl Med, 2012. 53:1892-1896.

4. Ludwig DR, Tanaka H, Friehling M, Gorcsan J, Schwartzman D. Further Deterioration of LV Ejection Fraction and Mechanical Synchrony During RV Apical Pacing in Patients with Heart Failure and LBBB. J Cardiovasc Transl Res, 2013. 6:425-429.

5. Friehling M, Ludwig DR, Dunn M, Soman P, Schwartzman D. Deterioration of left ventricular ejection fraction and contraction synchrony during right ventricular pacing in patients with left bundle branch block. J Nucl Cardiol, 2013. 20:830-834.

6. Onishi T, Saha SK, Ludwig DR, Onishi T, Marek J, Cavalcante J, Schelbert EB, Schwartzman D, Gorcsan J. Feature Tracking Measurement of Dyssynchrony from Cardiovascular Magnetic Resonance Cine Acquisitions: Comparison with Echocardiographic Speckle Tracking. J Cardiovas Magn Reson, 2013. 15(1):95.

7. Ludwig DR, Friehling M, Schelbert EB, Schwartzman D. Impact of infarction scar on SPECT assay of left ventricular mechanical dyssynchrony. Eur J Nucl Med Mol Imaging, 2014. 41(3):529-535.

8. Ahmed M, Gorcsan J 3rd, Marek J, Ryo K, Haugaa K, Ludwig DR, Schwartzman D. Right ventricular apical pacing-induced left ventricular dyssynchrony is associated with a subsequent decline in ejection fraction. Heart Rhythm, 2014. Epub ahead of print.

9. Friehling M, Menon PG, Ludwig DR, Schwartzman D. SPECT-MDCT fusion image integration: a potential aid to left ventricular substrate ablation. Europace, 2014 (in press).

PUBLISHED ABSTRACTS:

1. Schelbert EB, Testa SM, Meier CG, Ceyrolles WJ, Levenson JE, Blair AJ, Puntil KS, Kellman P, Jones BL, Ludwig DR, Zhong H, Schwartzman D, Shroff SG, Wong TC. Extracellular volume fraction measured by MOLLI: slow infusion versus bolus. J Cardiovasc Magn Reson, 2011.13(Suppl 1): P317.

2. Onishi T, Saha SK, Ludwig D, Onishi T, Oyenuga OA, Schelbert EB, Schwartzman D, Gorcsan J. Global Circumferential Strain from Routine Cardiac Magnetic Resonance Image Analysis Using a Novel Off-Line Approach: Comparison with Echocardiographic Strain and Left Ventricular Ejection Fraction. Circulation, 2011. 124: A11953.

3. Schelbert EB, Ceyrolles WJ, Testa SM, Meier CG, Ludwig DR, Blair AJ, Kellman, P, Schwartzman D, Shroff SG, Wong TC. Diffuse Myocardial Fibrosis Quantification by Cardiac MR is Strongly Associated with B-type Natriuretic Peptide (BNP) and Low Ejection Fraction: Implications for Paradigms of Myocardial Dysfunction. Circulation, 2011. 124: A18396.

4. Saha SK, Onishi T, Ludwig D, Schelbert EB, Schwartzman D, Gorcsan J. The utility of a novel off-line approach to quantify circumferential strain from routine cardiac magnetic resonance images: comparison with echocardiographic speckle tracking. Eur Heart J, 2011. 32(Abstract Suppl): 52.

5. Onishi T, Saha SK, Ludwig D, Schelbert E, Schwartzman D, Gorcsan J. Velocity vector imaging as a new approach for cardiac magnetic resonance: comparison with echocardiography. Eur Heart J, 2011. 32(Abstract Suppl): 374.

6. Onishi T, Saha SK, Ludwig D, Schelbert E, Schwartzman D, Gorcsan J. Global left ventricular circumferential strain is a marker for both systolic and diastolic myocardial function. Eur Heart J, 2011. 32(Abstract Suppl): 659.

7. Onishi T, Saha SK, Ludwig D, Onishi T, Ahmed M, Marek J, Schwartzman D, Gorcsan J. The Utility of a Novel Off-line Approach to Quantify Dyssynchrony from Routine Cardiac Magnetic Resonance Images: Comparison with Echocardiographic Speckle Tracking. J Am Coll Cardiol, 2012. 59: E1085.

8. Ludwig DR, Atri P, Friehling M, Schwartzman D, Soman P. SPECT Evaluation of the Effect of QRS Morphology and Mechanical Dysfunction on Left Ventricular Dyssynchrony. J Am Coll Cardiol, 2012. 59: E1182.

9. Ludwig DR, Friehling M, Shroff SG, Schwartzman D, Soman P. A new algorithm for SPECT-based dyssynchrony analysis in the presence of gating errors. J Nucl Med, 2012. 53(Supplement 1): 141.

10. Friehling M, Ludwig D, Schwartzman D, Soman P. On the Variability of Left Ventricular Motion Abnormality Associated with Intrinsic and Induced LBBB: Insights from SPECT Imaging. J Nucl Cardiol, 2012. 19(4): 117-18.

11. Ludwig DR, Friehling M, Dunn M, Schelbert E, Schwartzman D, Soman P. Improved Left Ventricular Scar Burden Assessment using SPECT. J Nucl Cardiol, 2012. 19(4): 125-12.

12. Ludwig DR, Friehling M, Schwartzman D, Soman P. SPECT Dyssynchrony Analysis: Selective Assessment of Non-scarred Myocardium. J Nucl Cardiol, 2012. 19(4): 117-15.

13. Ludwig DR, Friehling M, Schwartzman D, Saba S, Follansbee WP, Soman P. The Prevalence, Impact, and Post-hoc Correction of Gating Errors during SPECT Assessment of LV Dyssynchrony. J Nucl Cardiol, 2012. 19(4): 111-02.

14. Ludwig DR, Tanaka H, Friehling M, Gorcsan J, Schwartzman D. Intrinsic and Induced Left Bundle Branch Block are Not Interchangeable. Circulation, 2012. 126: A11123.

15. Haberman SC, Onishi T, Ludwig D, Schelbert E, Gorcsan J. Global Circumferential Strain by CMR Feature Tracking or Echocardiographic Speckle Tracking Strongly Predicts Clinical Outcomes in Patients with Systolic Heart Failure. J Am Coll Cardiol, 2013. 61: E605.

16. Ludwig DR, Menon PG, Friehling M, Schwartzman D. Feasibility of SPECT-CT Guided Left Ventricular Lead Deployment for Cardiac Resynchronization Therapy. J of Nucl Cardiol, 2013. 20(4): 203-08.

17. Delgado-Montero A, Onishi T, Saha S, Ludwig D, Onishi T, Schwartzman D, Gorcsan J. A simplified formula for estimation of ejection fraction from speckle tracking echocardiographic global strain: comparison with cardiac magnetic resonance. J Am Coll Cardiol, 2014 Apr; 63(12s1): A1164.

ORAL PRESENTATIONS:

1. Ludwig DR, Schwartzman D. SmartPace: A Software Suite to Maximize the Value of Pacemaker Therapy in Heart Failure. Funding pitch to CRT & Pacing Group at Medtronic. May 2, 2012. Minneapolis, MN.

2. Ludwig DR, Friehling M, Shroff SG, Schwartzman D, Soman P. A new algorithm for SPECT-based dyssynchrony analysis in the presence of gating errors. Oral presentation to the Society of Nuclear Medicine, June 9-13, 2012. Miami Beach, FL.

3. Ludwig DR, Friehling M, Schwartzman D, Saba S, Follansbee WP, Soman P. The Prevalence, Impact, and Post-hoc Correction of Gating Errors during SPECT Assessment of LV Dyssynchrony. Oral presentation to the American Society of Nuclear Cardiology. Sept 6-9, 2012. Baltimore, MD.

4. Ludwig DR, Friehling M, Soman P, Schwartzman D. Development of SPECT Imaging to Identify CRT-Remediable Dyssynchrony. Oral presentation at the University of Pittsburgh Physician Scientist Training Program Retreat. Aug 24, 2012. Pittsburgh, PA.

5. Ludwig DR, Menon PG, Friehling M, Schwartzman D. Feasibility of SPECT-CT guided left ventricular lead deployment for cardiac resynchronization therapy. Oral presentation at the American Heart Association Fellows Research Day. Feb 14, 2014. Pittsburgh, PA.

POSTER PRESENTATIONS:

1. Ludwig DR, Atri P, Friehling M, Schwartzman D. Soman P. SPECT Evaluation of the Effect of QRS Morphology and Mechanical Dysfunction on Left Ventricular Dyssynchrony. Poster presentation at the American Heart Association Fellows Research Day. Feb 17, 2012. Pittsburgh, PA.

2. Ludwig DR, Atri P, Friehling M, Schwartzman D. Soman P. SPECT Evaluation of the Effect of QRS Morphology and Mechanical Dysfunction on Left Ventricular Dyssynchrony. Poster presentation to the American College of Cardiology. March 24-27, 2012. Chicago, IL.

3. Ludwig DR, Friehling M, Dunn M, Schelbert E, Schwartzman D, Soman P. Improving the Accuracy of SPECT Left Ventricular Scar Burden Assessment. Poster presentation to the American Physician Scientist Association. April 27-29, 2012. Chicago, IL.

4. Ludwig DR, Friehling M, Dunn M, Schelbert E, Schwartzman D, Soman P. Improved Left Ventricular Scar Burden Assessment using SPECT. Poster presentation to the American Society of Nuclear Cardiology. Sept 6-9, 2012. Baltimore, MD.

5. Ludwig DR, Friehling M, Schwartzman D, Soman P. SPECT Dyssynchrony Analysis: Selective Assessment of Non-scarred Myocardium. Poster presentation to the American Society of Nuclear Cardiology. Sept 6-9, 2012. Baltimore, MD.

6. Ludwig DR, Tanaka H, Friehling M, Gorcsan J, Schwartzman D. Intrinsic and Induced Left Bundle Branch Block are Not Interchangeable. Poster presentation to the American Heart Association, November 3-7, 2012. Los Angeles, CA.

7. Ludwig DR, Menon PG, Friehling M, Schwartzman D. Feasibility of SPECT-CT Guided Left Ventricular Lead Deployment for Cardiac Resynchronization Therapy. Poster presentation to the American Society of Nuclear Cardiology. September 26-29, 2013. Chicago, IL.

PATENTS:

1. Ludwig D, Rhieu S, Palmore T. Determination of circulating 1alpha,25(OH)2D3 by enzyme electrode. WIPO Patent Application, 2010. WO/2010/014978.

2. Ludwig D, Schwartzman D, Friehling M. A System for Selection and Optimization of Patients Undergoing Cardiac Resynchronization Therapy. USPTO Provisional Application, 2012. Serial No.13/621,962.

3. Menon P, Schwartzman D, Ludwig D. Structure-function fusion for cardiac interventions. USPTO Provision Application. Serial No. 61/795,152.

AWARDS:
1. Morris H. and Gertrude M. Harris Foundation Scholarship (2010, 2013)

2. Pitt IEE Big Idea Competition Winner, Second Prize (2010), First Prize (2011), Runner-up (2012)

3. Pitt OED Michael G. Wells Student Entrepreneurship Competition, Finalist (2011)

4. American Society of Nuclear Cardiology Astellas Travel Award (2012)

5. American Society of Nuclear Cardiology Young Investigator Award, Runner-up (2012).